Research output per year
Research output per year
Project Details
Outline of Final Research Achievements
We have also developed new methodology to highlight promiscuous non-specific binding inhibitors of enzymes by interpreting the behavior of concentration-response curves under in vitro DMSO-perturbing assay conditions. Furthermore, we have discovered novel inhibitors of hyaluronan-degrading enzyme from natural plant extracts.
| Status | Finished |
|---|---|
| Effective start/end date | 2014/04/01 → 2017/03/31 |
Funding
- Japan Society for the Promotion of Science: ¥4,030,000.00
Keywords
- 生薬
- 多成分の分子変換
- アミノ酸誘導体
- ヒダントイン
- ヒアルロニダーゼ
- 化学的摂動効果
- ジメチルスルホキシド
- 非特異的分子間相互作用
- 多成分系の分子変換
- ヒアルロン酸分解酵素
- 化学的直接誘導化
- 非特異的阻害剤
- 複雑系
- 生薬成分抽出
- 化学的一挙誘導化
Research output
- 3 Article
-
Discovery of hyaluronidase inhibitors from natural products and their mechanistic characterization under DMSO-perturbed assay conditions
Tomohara, K., Ito, T., Onikata, S., Kato, A. & Adachi, I., 2017, In: Bioorganic and Medicinal Chemistry Letters. 27, 7, p. 1620-1623 4 p.Research output: Contribution to journal › Article › peer-review
14 Scopus citations -
Direct chemical derivatization of natural plant extract: Straightforward synthesis of natural plant-like hydantoin
Tomohara, K., Ito, T., Hasegawa, N., Kato, A. & Adachi, I., 2016/02/24, In: Tetrahedron Letters. 57, 8, p. 924-927 4 p.Research output: Contribution to journal › Article › peer-review
24 Scopus citations -
Interpreting the behavior of concentration-response curves of hyaluronidase inhibitors under DMSO-perturbed assay conditions
Tomohara, K., Ito, T., Onikata, S., Furusawa, K., Kato, A. & Adachi, I., 2016/07/01, In: Bioorganic and Medicinal Chemistry Letters. 26, 13, p. 3153-3157 5 p.Research output: Contribution to journal › Article › peer-review
8 Scopus citations