Manifestation of the HGF-related factor and influence of the invasion and proliferation in prostate cancer.

  • 布施, 秀樹 (Principal Investigator)
  • 保田, 賢司 (Co-Investigator(Kenkyū-buntansha))

Project Details

Abstract

We investigated manifestation in prostate cancer of hepatocyte growth factor activator(HGFA) inhibitor type 1(HAI-1). HAI-1 is inhibitor for HGFA. HAI-1 appeared in prostate epithelial cell, but did not appear in stromal cell by immunohistochemistry(IHC). Examination with prostate biopsy specimens, the HAI-1 expression was not observed for some case. We defined HAI-1 expression intensity as negative, weak, moderate and strong. We analyzed the relationship between HAI-1 expression and several clinicopathological factors. Expression of HAI-1 by IHC in patients with prostate cancer was significantly higher than those with negative for prostate biopsy. There were no significant differences in HAI-1 expression with respect to clinical stages or tumor grades. However castration resistance prostate cancer showed significantly lower HAI-1 expression than untreated metastatic prostate cancer.
StatusFinished
Effective start/end date2009/01/01 → 2011/12/31

Funding

  • Japan Society for the Promotion of Science: ¥3,250,000.00

Keywords

  • 腫瘍学
  • 癌
  • HAI-1
  • 転移・浸潤
  • HGF
  • 前立腺
  • HGF関連因子

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