Research output per year
Research output per year
Project Details
Abstract
Recent progress in the drug developments enables the computer aided design of new medicines which are often called as "molecular target drugs." The present research developed several novel photo-activatable probes that are effective for the analysis trace amount proteins. The application of this purobe was successful for solving important binding-site within a metabolic enzyme.
| Status | Finished |
|---|---|
| Effective start/end date | 2008/01/01 → 2010/12/31 |
Funding
- Japan Society for the Promotion of Science: ¥19,370,000.00
Keywords
- 創薬基礎技術
- 薬物結合部位
- 質量分析
- 光アフィニティー
- 光プローブ
- 膜タンパク質
- 機能部位
- 構造解析
- ペルオキシソーム
- β-酸化酵素
- ATP
- 固相技術
Research output
- 4 Article
-
Rapidly photoactivatable ATP probes for specific labeling of tropomyosin within the actomyosin protein complex
Masuda, S., Tomohiro, T. & Hatanaka, Y., 2011/04/15, In: Bioorganic and Medicinal Chemistry Letters. 21, 8, p. 2252-2254 3 p.Research output: Contribution to journal › Article › peer-review
6 Scopus citations -
Efficient approach for profiling photoaffinity labeled peptides with a cleavable biotinyl photoprobe
Bongo, N. B., Tomohiro, T. & Hatanaka, Y., 2010/03/15, In: Bioorganic and Medicinal Chemistry Letters. 20, 6, p. 1834-1836 3 p.Research output: Contribution to journal › Article › peer-review
6 Scopus citations -
Identification of a substrate-binding site in a peroxisomal β-oxidation enzyme by photoaffinity labeling with a novel palmitoyl derivative
Kashiwayama, Y., Tomohiro, T., Narita, K., Suzumura, M., Glumoff, T., Hiltunen, J. K., Van Veldhoven, P. P., Hatanaka, Y. & Imanaka, T., 2010/08/20, In: Journal of Biological Chemistry. 285, 34, p. 26315-26325 11 p.Research output: Contribution to journal › Article › peer-review
Open Access11 Scopus citations