A new strategy for antibody-therapy against infectious diseases and bacterial terrorism using lymphocyte-chip

  • 村口　篤 (Principal Investigator)
  • 岸, 裕幸 (Co-Investigator(Kenkyū-buntansha))
  • 小澤, 龍彦 (Co-Investigator(Kenkyū-buntansha))
  • 北島勲 (Co-Investigator(Kenkyū-buntansha))
  • 二階堂敏雄. (Co-Investigator(Kenkyū-buntansha))

Project Details

Abstract

We developed ISAAC (Immunospot assay for antibody-secreting cell) method that can detect antibody-secreting cells in a microwell using murine system. We then succeeded in generating high-quality human monoclonal antibodies for hepatitis B virus and influenza virus from vaccinated healthy volunteers using the ISAAC method in a very short time ; within one week. We further developed an in vitro assay system to examine the HBV-neutralizing activity of human anti-HBs antibodies and clarified the relationship between neutralizing activity of human mAbs and epitopes of HBs antigen.
StatusFinished
Effective start/end date2008/01/01 → 2010/12/31

Funding

  • Japan Society for the Promotion of Science: ¥18,850,000.00

Keywords

  • リンパ球チップ
  • 抗体医療
  • 抗体遺伝子
  • 抗体産生細胞
  • リコンビナント抗体
  • インフルエンザウイルス
  • B型肝炎ウイルス
  • 中和抗体
  • 抗体医薬
  • 感染症
  • 抗体工学
  • ヒト抗体
  • 新興感染症

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