Research output per year
Research output per year
Project Details
Abstract
Trypanosome has glycosome that resembles to human peroxisome. Impaired biogenesis of glycosome is known to show fatal effect for trypanosome. As an application of the knowledge about biogenesis of peroxisome, we tried to develop the therapeutic compounds for trypanosomiasis. We established a high thoughput screening system to identify chemical compounds that inhibit the interaction between Pex5p and Pex14p. Using this screening system, we started to screen chemical libraries to find effective compounds.
| Status | Finished |
|---|---|
| Effective start/end date | 2011/01/01 → 2013/12/31 |
Funding
- Japan Society for the Promotion of Science: ¥5,330,000.00
Keywords
- ペルオキシソーム
- グリコソーム
- ペルオキシソーム膜形成
- 膜タンパク質局在化
- トリパノソーマ感染症治療薬
- ハイスループットスクリーニング
- トリパノソーマ感染治療薬
- タンパク質局在化
- 原虫治療薬
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A novel double mutation in the ABCD1 gene in a patient with x-linked adrenoleukodystrophy: Analysis of the stability and function of the mutant ABCD1 protein
Morita, M., Kobayashi, J., Yamazaki, K., Kawaguchi, K., Honda, A., Sugai, K., Shimozawa, N., Koide, R. & Imanaka, T., 2013, JIMD Reports. Springer, p. 95-102 8 p. (JIMD Reports; vol. 10).Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review
Open Access13 Scopus citations -
Molecular species of phospholipids with very long chain fatty acids in skin fibroblasts of Zellweger syndrome
Hama, K., Nagai, T., Nishizawa, C., Ikeda, K., Morita, M., Satoh, N., Nakanishi, H., Imanaka, T., Shimozawa, N., Taguchi, R., Inoue, K. & Yokoyama, K., 2013/12, In: Lipids. 48, 12, p. 1253-1267 15 p.Research output: Contribution to journal › Article › peer-review
18 Scopus citations -
Peroxisomal ABC transporters: Structure, function and role in disease
Morita, M. & Imanaka, T., 2012/09, In: Biochimica et Biophysica Acta - Molecular Basis of Disease. 1822, 9, p. 1387-1396 10 p.Research output: Contribution to journal › Review article › peer-review
Open Access153 Scopus citations