Novel stereoselective synthesis of the spiroketal structure using Pd(II) catalyst and application to the synthesis of natural products

  • 宮澤, 眞宏 (Principal Investigator)

Project Details

Abstract

We have developed highly stereoselective intamolecular cyclization of dihydroxyketone using palladium(II) catalyst via hemiacetal, in which cyclization occurs without activation of the allylic alcohol to afford spiroketal structures. We have also synthesized some monosaccharide such as D-ribose and deoxy-D-ribose used by this cascade cyclization. And we succeed in the stereoselective synthesis of spiroketal structures of spirofungin A and bistramide A.
StatusFinished
Effective start/end date2009/01/012011/12/31

Funding

  • Japan Society for the Promotion of Science: ¥4,680,000.00

Keywords

  • 選択的合成
  • パラジウム
  • スピロケタール
  • 連続環化
  • ポリプロピオネート
  • パラジムウ触媒
  • ヘミアセタール
  • ヘテロ環化反応
  • 立体選択的
  • スピロファンジン
  • ビストラミド
  • パプラカンジン
  • パラジウム触媒