We have developed highly stereoselective intamolecular cyclization of dihydroxyketone using palladium(II) catalyst via hemiacetal, in which cyclization occurs without activation of the allylic alcohol to afford spiroketal structures. We have also synthesized some monosaccharide such as D-ribose and deoxy-D-ribose used by this cascade cyclization. And we succeed in the stereoselective synthesis of spiroketal structures of spirofungin A and bistramide A.
Status
Finished
Effective start/end date
2009/01/01 → 2011/12/31
Funding
Japan Society for the Promotion of Science: ¥4,680,000.00