Physical and mental health must be maintained to improve the quality of life of the elderly. This study aimed to obtain basic knowledge regarding the design of textile end-uses that can support the age-related physical and mental changes and everyday lives of elderly people. Physiological activity, such as electromyogram, brain waves, heart rate, and blood flow, was measured using underwear, socks, gardening gloves, and disposable adult diapers, and we examined the relationship between the properties/performance of the textile end-uses and physiological response. As a result,we developed specific design guidelines for elderly-friendly textile end-uses.