Molecular mechanism and pathophysiology of nucleophagy induced by cation pump

Project Details

Description

In this research, the molecular mechanism and pathophysiology of nucleophagy induced by human ATP13A4 were examined. We found that human ATP13A4 had no ion-transporting function and its N-terminal region was essential for induction of nucleophagy. On the other hand, mouse ATP13A4 had cation-transporting function and did not induce nucleophagy. Related proteins for the ATP13A4-induced nucleophagy were identified by DNA microarray and proteomics. Especially, increased expression levels of proteins involved in proteolytic system and cellular stress response were observed in human ATP13A4-expressing cells.
StatusFinished
Effective start/end date2012/04/012014/03/31

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