Research output per year
Research output per year
Project Details
Abstract
In addition to the involvement of proteinases on the induction of itch in atopic dermatitis, the mechanisms were also investigated. This study demonstrated that serine proteinases, such as tryptase, and proteinase-activated receptor-2 (PAR_2) played an important role on the induction of itch in atopic dermatitis. In addition to keratinocytes, PAR_2 is expressed on primary afferents. Thus, PAR_2-expressed primary afferent is important on the transmission of itch in atopic dermatitis.
| Status | Finished |
|---|---|
| Effective start/end date | 2007/01/01 → 2009/12/31 |
Funding
- Japan Society for the Promotion of Science: ¥3,730,000.00
Keywords
- かゆみ
- プロテアーゼ
- アトピー性皮膚炎
- 皮膚
- マスト細胞
- PAR-2
- 一次感覚神経
- 痒み
- アスパラギン酸プロテアーゼ
- セリンプロテアーゼ
- マウス
- T細胞
- カリクレイン
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Involvement of tryptase and proteinase-activated receptor-2 in spontaneous itch-associated response in mice with atopy-like dermatitis
Tsujii, K., Andoh, T., Ui, H., Lee, J. B. & Kuraishi, Y., 2009, In: Journal of Pharmacological Sciences. 109, 3, p. 388-395 8 p.Research output: Contribution to journal › Article › peer-review
Open Access63 Scopus citations -
Itch-related responses of dorsal horn neurons to cutaneous allergic stim ulation
Andoh, T., 2009.Research output: Contribution to conference › Presentation
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Itch-related responses of dorsal horn neurons to cutaneous allergic stimulation in mice
Omori, Y., 2009, In: Neuroreport 20. p. 478-481Research output: Contribution to journal › Article › peer-review