Functional analysis of synapse morphology regulated by MKL, an actin-binding coactivator

  • Ishikawa, Mitsuru (Principal Investigator)

Project Details

Abstract

In characterizing MKL1 transcripts expressed in rat brain, we have identified a novel transcript in addition to the other two transcripts. Functional comparison of these isoforms with regard to their ability to localize to the nucleus, drive SRE-mediated transcription and dendritic morphology revealed that one of the MKL1 isoforms is more active than the others in all these assays.
StatusFinished
Effective start/end date2011/01/01 → 2011/12/31

Funding

  • Japan Society for the Promotion of Science: ¥1,690,000.00

Keywords

  • アクチン
  • SRF
  • 転写因子
  • 樹状突起
  • Rho

Access Project