Establishment of diffuse alveolar damage induced by hyperoxia exposure in mice and elucidation of its pathogenesis

  • 島田, 一郎 (Principal Investigator)
  • 滝澤, 久夫 (Co-Investigator(Kenkyū-buntansha))
  • 畑, 由紀子 (Co-Investigator(Kenkyū-buntansha))

Project Details

Abstract

Moreover we confirmed apoptotic conditions, such as significant up-regulations of mRNA levels in Galectin-3 and Myc using real-time qPCR. Hyperoxic condition probably yielded reactive oxygen species (ROS), which resulted in a malignant cycle of ROS production by Myc overexpression.
StatusFinished
Effective start/end date2005/01/01 → 2006/12/31

Funding

  • Japan Society for the Promotion of Science: ¥3,600,000.00

Keywords

  • びまん性肺胞障害
  • 高濃度酸素曝露
  • マウス(C57BL
  • 6J)
  • ハムスター(Slc : Syrian)
  • ラット(Slc : Wistar
  • ST)
  • 肺胞中隔の線維化
  • 免疫
  • 組織改築
  • 瀰漫性肺胞傷害
  • びまん性肺胞傷害
  • ハムスター(Slc:Syrian)
  • ラット(Slc:Wistar
  • 線維化
  • 生体防禦
  • Diffuse alveolar damage
  • Hyperoxia exposure
  • Gene expression
  • Myc
  • Galectin-3
  • Connective tissue growth factor
  • Surfactant-associated protein C
  • Lysozyme

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