Takanori So

2024

Generation and characterization of OX40-ligand fusion protein that agonizes OX40 on T-Lymphocytes

Sato, A., Nagai, H., Suzuki, A., Ito, A., Matsuyama, S., Shibui, N., Morita, M., Hikosaka-Kuniishi, M., Ishii, N. & So, T., 2024, In: Frontiers in Immunology. 15, 1473815.

Research output: Contribution to journal › Article › peer-review

Open Access

Increased neurotoxicity of high-density lipo- protein secreted from murine reactive astrocytes deficient in a peroxisomal very-long-chain fatty acid transporter Abcd1.

N, F., T, A., M, S., M, M., T, S. & K., O., 2024, In: J. Inherit. Metab. Dis 31. 47, 2, p. 289-301

Research output: Contribution to journal › Article › peer-review

The Role of TNF Receptor-Associated Factor 5 in the Formation of Germinal Centers by B Cells During the Primary Phase of the Immune Response in Mice

Hikosaka-Kuniishi, M., Iwata, C., Ozawa, Y., Ogawara, S., Wakaizumi, T., Itaya, R., Sunakawa, R., Sato, A., Nagai, H., Morita, M. & So, T., 2024/11, In: International Journal of Molecular Sciences. 25, 22, 12331.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Transmembrane helix 6 of ABCD4 is indispensable for cobalamin transport

Imai, M., Kawaguchi, K., Morita, M., Imanaka, T. & So, T., 2024/03, In: Journal of Inherited Metabolic Disease. 47, 2, p. 366-373 8 p.

Research output: Contribution to journal › Article › peer-review

2023

Fundamental Characterization of Antibody Fusion-Single-Chain TNF Recombinant Proteins Directed against Costimulatory TNF Receptors Expressed by T-Lymphocytes

Nagai, H., Azuma, M., Sato, A., Shibui, N., Ogawara, S., Tsutsui, Y., Suzuki, A., Wakaizumi, T., Ito, A., Matsuyama, S., Morita, M., Hikosaka Kuniishi, M., Ishii, N. & So, T., 2023/06, In: Cells. 12, 12, 1596.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Scopus citations

Fundamental Characterization of Antibody Fusion-Single-Chain TNF Recombinant Proteins Directed against Costimulatory TNF Receptors Expressed by T-Lymphocytes

Nagai, H., Azuma, M., Sato, A., Shibui, N., Ogawara, S., Tsutsui, Y., Suzuki, A., Wakaizumi, T., Ito, A., Matsuyama, S., Morita, M., Hikosaka Kuniishi, M., Ishii, N. & So, T., 2023/06/09, In: Cells. 12, 12

Research output: Contribution to journal › Article › peer-review

Increased neurotoxicity of high-density lipoprotein secreted from murine reactive astrocytes deficient in a peroxisomal very-long-chain fatty acid transporter Abcd1

Fujitani, N., Akashi, T., Saito, M., Morita, M., So, T. & Oka, K., 2023/12/25, (E-pub ahead of print) In: Journal of Inherited Metabolic Disease.

Research output: Contribution to journal › Article › peer-review

Role of tumor necrosis factor receptor-associated factor 5 in B- and T-lymphocytes

Hikosaka Kuniishi, M., Ishii, N. & So, T., 2023/02/27, In: Exploration of Immunology. p. 40-55 16 p.

Research output: Contribution to journal › Article › peer-review

2022

Detection of Characteristic Phosphatidylcholine Containing Very Long Chain Fatty Acids in Cerebrospinal Fluid from Patients with X-Linked Adrenoleukodystrophy

Fujitani, N., Saito, M., Akashi, T., Morita, M., So, T. & Oka, K., 2022/11, In: Biological and Pharmaceutical Bulletin. 45, 11, p. 1725-1727 3 p.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

Functional Analysis of the Transcriptional Regulator IκB-ζ in Intestinal Homeostasis

Sasaki, T., Nagashima, H., Okuma, A., Yamauchi, T., Yamasaki, K., Aiba, S., So, T., Ishii, N., Owada, Y., MaruYama, T. & Kobayashi, S., 2022/04, In: Digestive Diseases and Sciences. 67, 4, p. 1252-1259 8 p.

Research output: Contribution to journal › Article › peer-review

OX40 Ligand-Mannose-Binding Lectin Fusion Protein Induces Potent OX40 Cosignaling in CD4⁺ T Cells

Sato, A., Azuma, M., Nagai, H., Imai, W., Kawaguchi, K., Morita, M., Okuyama, Y., Ishii, N. & So, T., 2022/12, In: Biological and Pharmaceutical Bulletin. 45, 12, p. 1798-1804 7 p.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

The immunological significance of tumor necrosis factor receptor-associated factors (TRAFs).

So, T., 2022/01/01, In: International Immunology. 34, 1, p. 7-20 14 p.

Research output: Contribution to journal › Article

31 Citations (SciVal)

TNF Receptor-Associated Factor 5 Limits IL-27 Receptor Signaling in CD4+ T Lymphocytes.

Kawahara, E., Azuma, M., Nagashima, H., Omori, K., Akiyama, S., Fujimori, Y., Oishi, M., Shibui, N., Kawaguchi, K., Morita, M., Okuyama, Y., Ishii, N. & So, T., 2022/02/01, In: Journal of immunology (Baltimore, Md. : 1950). 208, 3, p. 642-650 9 p.

Research output: Contribution to journal › Article

6 Scopus citations

2021

Acyl-CoA thioesterase activity of peroxisomal ABC protein ABCD1 is required for the transport of very long-chain acyl-CoA into peroxisomes

Kawaguchi, K., Mukai, E., Watanabe, S., Yamashita, A., Morita, M., So, T. & Imanaka, T., 2021/12, In: Scientific Reports. 11, 1, 2192.

Research output: Contribution to journal › Article › peer-review

Open Access

15 Scopus citations

Bone marrow transplantation into Abcd1-deficient mice: Distribution of donor derived-cells and biological characterization of the brain of the recipient mice

Morita, M., Kaizawa, T., Yoda, T., Oyama, T., Asakura, R., Matsumoto, S., Nagai, Y., Watanabe, Y., Watanabe, S., Kobayashi, H., Kawaguchi, K., Yamamoto, S., Shimozawa, N., So, T. & Imanaka, T., 2021/05, In: Journal of Inherited Metabolic Disease. 44, 3, p. 718-727 10 p.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Generation of an immortalized astrocytic cell line from Abcd1-deficient H-2K^btsA58 mice to facilitate the study of the role of astrocytes in X-linked adrenoleukodystrophy

Morita, M., Toida, A., Horiuchi, Y., Watanabe, S., Sasahara, M., Kawaguchi, K., So, T. & Imanaka, T., 2021/02, In: Heliyon. 7, 2, e06228.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

The lysosomal protein ABCD4 can transport Vitamin B₁₂ across liposomal membranes in vitro

Kitai, K., Kawaguchi, K., Tomohiro, T., Morita, M., So, T. & Imanaka, T., 2021/01/01, In: Journal of Biological Chemistry. 296, 100654.

Research output: Contribution to journal › Article › peer-review

Open Access

18 Scopus citations

2020

Biallelic variants/mutations of IL1RAP in patients with steroid-sensitive nephrotic syndrome

Niitsuma, S., Kudo, H., Kikuchi, A., Hayashi, T., Kumakura, S., Kobayashi, S., Okuyama, Y., Kumagai, N., Niihori, T., Aoki, Y., So, T., Funayama, R., Nakayama, K., Shirota, M., Kondo, S., Kagami, S., Tsukaguchi, H., Iijima, K., Kure, S. & Ishii, N., 2020/04/01, In: International Immunology. 32, 4, p. 283-292 10 p.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

GITR controls intestinal inflammation by suppressing IL-15-dependent NK cell activity

Sakurai, T., Okuyama, Y., Kobayashi, S., Phung, H. T., Asao, A., Kawabe, T., Ndhlovu, L. C., Riccardi, C., Kudo, H., Wada, M., Nio, M., So, T. & Ishii, N., 2020/11/01, In: FASEB Journal. 34, 11, p. 14820-14831 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

IQGAP1 restrains T-cell cosignaling mediated by OX40

Okuyama, Y., Nagashima, H., Ushio-Fukai, M., Croft, M., Ishii, N. & So, T., 2020/01/01, In: FASEB Journal. 34, 1, p. 540-554 15 p.

Research output: Contribution to journal › Article › peer-review

Open Access

12 Scopus citations

Iq motif-containing gtpase-activating protein 1 is essential for the optimal maintenance of lung ilc2s

Tayama, S., Okuyama, Y., Phung, H. T., Asao, A., Kobayashi, S., Musha, T., MacHiyama, T., Sakurai, T., Zhang, C., Ushio-Fukai, M., Kawabe, T., So, T. & Ishii, N., 2020/04/01, In: International Immunology. 32, 4, p. 233-241 9 p.

Research output: Contribution to journal › Article › peer-review

TRAF5 Deficiency Ameliorates the Severity of Dextran Sulfate Sodium Colitis by Decreasing TRAF2 Expression in Nonhematopoietic Cells

Phung, H. T., Nagashima, H., Kobayashi, S., Asano, N., Machiyama, T., Sakurai, T., Tayama, S., Asao, A., Imatani, A., Kawabe, T., Okuyama, Y., Ishii, N. & So, T., 2020/04/01, In: ImmunoHorizons. 4, 4, p. 129-139 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

3 Scopus citations

TRAF5 Deficiency Ameliorates the Severity of Dextran Sulfate Sodium Colitis by Decreasing TRAF2 Expression in Nonhematopoietic Cells.

Phung, H. T., Nagashima, H., Kobayashi, S., Asano, N., Machiyama, T., Sakurai, T., Tayama, S.-I., Asao, A., Imatani, A., Kawabe, T., Okuyama, Y., Ishii, N. & So, T., 2020/03/10, In: ImmunoHorizons. 4, 3, p. 129-139 11 p.

Research output: Contribution to journal › Article

TRAF5 promotes plasmacytoid dendritic cell development from bone marrow progenitors

Kobayashi, S., Shiota, Y., Kawabe, T., Phung, H. T., Maruyama, T., Owada, Y., So, T. & Ishii, N., 2020/01/08, In: Biochemical and Biophysical Research Communications. 521, 2, p. 353-359 7 p.

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

2019

Biallelic variants/mutations of IL1RAP in patients with steroid-sensitive nephrotic syndrome

Sou, N., Hiroki, K., Atsuo, K., Takaya, H., Satoshi, K., Shuhei, K., Yuko, O., Naonori, K., Tetsuya, N., Yoko, A., Takanori, S., Ryo, F., Keiko, N., Matsuyuki, S., Shuji, K., Shoji, K., Hiroyasu, T., Kazumoto, I., Shigeo, K. & Naoto, I., 2019, In: International Immunology. -, 4, p. 283-292

Research output: Contribution to journal › Article › peer-review

IQGAP1 restrains T‐cell cosignaling mediated by OX40

Yuko, O., Hiroyuki, N., Masuko, U., Michael, C., Naoto, I. & Takanori, S., 2019, In: The FASEB Journal 22. 34, 1, p. 540-554

Research output: Contribution to journal › Article › peer-review

IQ motif-containing GTPase-activating protein 1 is essential for the optimal maintenance of lung ILC2s

Shunichi, T., Yuko, O., Hai The, P., Atsuko, A., Shuhei, K., Tomomi, M., Tomoaki, M., Tsuyoshi, S., Chengming, Z., Masuko, U.-F., Takeshi, K., Takanori, S. & Naoto, I., 2019, In: International Immunology. -, 4, p. 233-241

Research output: Contribution to journal › Article › peer-review

TNF receptor-associated factor 5 limits function of plasmacytoid dendritic cells by controlling IFN regulatory factor 5 expression

Kobayashi, S., Sakurai, T., So, T., Shiota, Y., Asao, A., Phung, H. T., Tanaka, R., Kawabe, T., Maruyama, T., Kanno, E., Kawakami, K., Owada, Y. & Ishii, N., 2019/09/15, In: Journal of Immunology. 203, 6, p. 1447-1456 10 p.

Research output: Contribution to journal › Article › peer-review

Open Access

8 Scopus citations

2018

GITR cosignal in ILC2s controls allergic lung inflammation

Nagashima, H., Okuyama, Y., Fujita, T., Takeda, T., Motomura, Y., Moro, K., Hidaka, T., Omori, K., Sakurai, T., Machiyama, T., Ndhlovu, L. C., Riccardi, C., So, T. & Ishii, N., 2018/05, In: Journal of Allergy and Clinical Immunology. 141, 5, p. 1939-1943.e8

Research output: Contribution to journal › Article › peer-review

Open Access

48 Scopus citations

TNF receptor associated factor 5 controls oncostatin M-mediated lung inflammation

Machiyama, T., So, T., Okuyama, Y., Kobayashi, S., Phung, H. T., Asao, A., Harigae, H. & Ishii, N., 2018/05/15, In: Biochemical and Biophysical Research Communications. 499, 3, p. 544-550 7 p.

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

TRAF2 and TRAF5 associated with the signal transducing receptor gp130 limit IL-6-driven transphosphorylation of JAK1 through the inhibition of proximal JAK-JAK interaction

Kimura, M., Nagashima, H., Okuyama, Y., Ishii, N. & So, T., 2018/06/26, In: International Immunology. 30, 7, p. 291-299 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

9 Citations (SciVal)

2016

Mesenteric lymph nodes contribute to proinflammatory Th17-cell generation during inflammation of the small intestine in mice

Kawabe, T., Suzuki, N., Yamaki, S., Sun, S. L., Asao, A., Okuyama, Y., So, T., Iwakura, Y. & Ishii, N., 2016/05/01, In: European Journal of Immunology. 46, 5, p. 1119-1131 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

17 Scopus citations

Relationship between the magnitude of IgE production in mice and conformational stability of the house dust mite allergen, Der p 2

Nakamura, H., Ohkuri, T., So, T. & Ueda, T., 2016/10/01, In: BBA - General Subjects. 1860, 10, p. 2279-2284 6 p.

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

TNFR-associated factors 2 and 5 differentially regulate the instructive IL-6 receptor signaling required for Th17 development

Nagashima, H., Okuyama, Y., Hayashi, T., Ishii, N. & So, T., 2016/05/15, In: Journal of Immunology. 196, 10, p. 4082-4089 8 p.

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

2015

OX40 ligand expressed in glioblastoma modulates adaptive immunity depending on the microenvironment: A clue for successful immunotherapy

Shibahara, I., Saito, R., Zhang, R., Chonan, M., Shoji, T., Kanamori, M., Sonoda, Y., Kumabe, T., Kanehira, M., Kikuchi, T., So, T., Watanabe, T., Takahashi, H., Iwabuchi, E., Tanaka, Y., Shibahara, Y., Sasano, H., Ishii, N. & Tominaga, T., 2015/02/15, In: Molecular Cancer. 14, 1, 41.

Research output: Contribution to journal › Article › peer-review

Open Access

39 Scopus citations

TRAF5はIL-6シグナルを制御することでT[H]17分化を抑制する

宗孝紀, 2015/04, In: 臨床免疫・アレルギー科 = Clinical immunology & allergology / 臨床免疫・アレルギー科編集委員会編. 63, 4, p. 396-400 5 p.

Research output: Contribution to journal › Article

TRAF5を介したシグナル伝達

宗孝紀 & 石井直人, 2015, In: 分子消化器病. 12, p. 399-403 5 p.

Research output: Contribution to journal › Article

2014

Activation of Notch1 promotes development of human CD8⁺ single positive T cells in humanized mice

Haji, Y., Suzuki, M., Moriya, K., So, T., Hozumi, K., Mizuma, M., Unno, M. & Ishii, N., 2014/05/02, In: Biochemical and Biophysical Research Communications. 447, 2, p. 346-351 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

7 Scopus citations

OX40 and IL-7 play synergistic roles in the homeostatic proliferation of effector memory CD4⁺ T cells

Yamaki, S., Ine, S., Kawabe, T., Okuyama, Y., Suzuki, N., Soroosh, P., Mousavi, S. F., Nagashima, H., Sun, S. L., So, T., Sasaki, T., Harigae, H., Sugamura, K., Kudo, H., Wada, M., Nio, M. & Ishii, N., 2014/10/01, In: European Journal of Immunology. 44, 10, p. 3015-3025 11 p.

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

The adaptor TRAF5 limits the differentiation of inflammatory CD4 + T cells by antagonizing signaling via the receptor for IL-6

Nagashima, H., Okuyama, Y., Asao, A., Kawabe, T., Yamaki, S., Nakano, H., Croft, M., Ishii, N. & So, T., 2014/05, In: Nature Immunology. 15, 5, p. 449-456 8 p.

Research output: Contribution to journal › Article › peer-review

Open Access

38 Scopus citations

ヘルパーT細胞分化におけるTRAF5を介したチェックポイント制御

宗孝紀 & 石井直人, 2014, In: 炎症と免疫. 23, p. 21-26 6 p.

Research output: Contribution to journal › Article

2013

Gene Therapy Model of X-linked Severe Combined Immunodeficiency Using a Modified Foamy Virus Vector

Horino, S., Uchiyama, T., So, T., Nagashima, H., Sun, S. L., Sato, M., Asao, A., Haji, Y., Sasahara, Y., Candotti, F., Tsuchiya, S., Kure, S., Sugamura, K. & Ishii, N., 2013/08/21, In: PLoS ONE. 8, 8, e71594.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Scopus citations

Homeostatic proliferation of naive CD4⁺ T cells in mesenteric lymph nodes generates gut-tropic Th17 cells

Kawabe, T., Sun, S. L., Fujita, T., Yamaki, S., Asao, A., Takahashi, T., So, T. & Ishii, N., 2013/06/01, In: Journal of Immunology. 190, 11, p. 5788-5798 11 p.

Research output: Contribution to journal › Article › peer-review

Open Access

43 Scopus citations

OX40とIL-7によるメモリーCD4+T細胞の維持機構 (特集 T細胞のメモリー・エフェクターへの分化と関与分子)

宗孝紀 & 石井直人, 2013/05, In: 臨床免疫・アレルギー科 = Clinical immunology & allergology / 臨床免疫・アレルギー科編集委員会編. 59, 5, p. 559-566 8 p.

Research output: Contribution to journal › Article

Regulation of PI-3-kinase and Akt signaling in T lymphocytes and other cells by TNFR family molecules

So, T. & Croft, M., 2013, In: Frontiers in Immunology. 4, JUN, Article 139.

Research output: Contribution to journal › Article › peer-review

Open Access

109 Scopus citations

Y chromosome-linked B and NK cell deficiency in mice

Sun, S. L., Horino, S., Itoh-Nakadai, A., Kawabe, T., Asao, A., Takahashi, T., So, T., Funayama, R., Kondo, M., Saitsu, H., Matsumoto, N., Nakayama, K. & Ishii, N., 2013/06/15, In: Journal of Immunology. 190, 12, p. 6209-6220 12 p.

Research output: Contribution to journal › Article › peer-review

Open Access

19 Scopus citations

2012

TNFスーパーファミリーの分子進化とT細胞シグナル制御

宗孝紀, 2012/02, In: Seikagaku. 84, 2, p. 102-106 5 p.

Research output: Contribution to journal › Article › peer-review

2011

Antigen-independent signalosome of CARMA1, PKCθ, and TNF receptor-associated factor 2 (TRAF2) determines NF-κB signaling in T cells

So, T., Soroosh, P., Eun, S. Y., Altman, A. & Croft, M., 2011/02/15, In: Proceedings of the National Academy of Sciences of the United States of America. 108, 7, p. 2903-2908 6 p.

Research output: Contribution to journal › Article › peer-review

Open Access

50 Scopus citations

Herpesvirus entry mediator (TNFRSF14) regulates the persistence of T helper memory cell populations

Soroosh, P., Doherty, T. A., So, T., Mehta, A. K., Khorram, N., Norris, P. S., Scheu, S., Pfeffer, K., Ware, C. & Croft, M., 2011/04/11, In: Journal of Experimental Medicine. 208, 4, p. 797-809 13 p.

Research output: Contribution to journal › Article › peer-review

Open Access

63 Scopus citations

Inducible CD4 ⁺LAP ⁺Foxp3 ^- regulatory T cells suppress allergic inflammation

Duan, W., So, T., Mehta, A. K., Choi, H. & Croft, M., 2011/12/15, In: Journal of Immunology. 187, 12, p. 6499-6507 9 p.

Research output: Contribution to journal › Article › peer-review

Open Access

56 Scopus citations

Takanori So

Research output

Search results