Pentagalloylglucose down-regulates mast cell surface FcεRI expression in vitro and in vivo

Natsuko Kageyama-Yahara; Yoko Suehiro; Futoshi Maeda; Shun ichiro Kageyama; Junya Fukuoka; Tatsuo Katagiri; Takeshi Yamamoto; Makoto Kadowaki

doi:10.1016/j.febslet.2009.11.007

Pentagalloylglucose down-regulates mast cell surface FcεRI expression in vitro and in vivo

Natsuko Kageyama-Yahara^*, Yoko Suehiro, Futoshi Maeda, Shun ichiro Kageyama, Junya Fukuoka, Tatsuo Katagiri, Takeshi Yamamoto, Makoto Kadowaki

^*この論文の責任著者

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

36 被引用数 (Scopus)

抄録

Mast cell activation by immunoglobulin E (IgE)-mediated stimuli is a central event in the pathogenesis of allergic disorders. The present report shows that treatment with pentagalloylglucose (PGG) resulted in a down-regulation of FcεRI surface expression on mucosal-type murine bone marrow-derived mast cells (mBMMCs), which correlated with a reduction in IgE-mediated activation of mBMMCs. Furthermore, PGG prevented development of allergic diarrhea in a food-allergy mouse model and suppressed the up-regulated FcεRI surface expression on mast cells derived from the food-allergy mouse colon. These findings on PGG suggest its therapeutic potential for allergic diseases through suppressing the FcεRI surface expression.

本文言語	英語
ページ（範囲）	111-118
ページ数	8
ジャーナル	FEBS Letters
巻	584
号	1
DOI	https://doi.org/10.1016/j.febslet.2009.11.007
出版ステータス	出版済み - 2010/01/04

ASJC Scopus 主題領域

生物理学
構造生物学
生化学
分子生物学
遺伝学
細胞生物学

文献へのアクセス

10.1016/j.febslet.2009.11.007

引用スタイル

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title = "Pentagalloylglucose down-regulates mast cell surface FcεRI expression in vitro and in vivo",

abstract = "Mast cell activation by immunoglobulin E (IgE)-mediated stimuli is a central event in the pathogenesis of allergic disorders. The present report shows that treatment with pentagalloylglucose (PGG) resulted in a down-regulation of FcεRI surface expression on mucosal-type murine bone marrow-derived mast cells (mBMMCs), which correlated with a reduction in IgE-mediated activation of mBMMCs. Furthermore, PGG prevented development of allergic diarrhea in a food-allergy mouse model and suppressed the up-regulated FcεRI surface expression on mast cells derived from the food-allergy mouse colon. These findings on PGG suggest its therapeutic potential for allergic diseases through suppressing the FcεRI surface expression.",

keywords = "Allergy, Gene expression, Mast cell",

author = "Natsuko Kageyama-Yahara and Yoko Suehiro and Futoshi Maeda and Kageyama, {Shun ichiro} and Junya Fukuoka and Tatsuo Katagiri and Takeshi Yamamoto and Makoto Kadowaki",

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doi = "10.1016/j.febslet.2009.11.007",

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T1 - Pentagalloylglucose down-regulates mast cell surface FcεRI expression in vitro and in vivo

AU - Kageyama-Yahara, Natsuko

AU - Suehiro, Yoko

AU - Maeda, Futoshi

AU - Kageyama, Shun ichiro

AU - Fukuoka, Junya

AU - Katagiri, Tatsuo

AU - Yamamoto, Takeshi

AU - Kadowaki, Makoto

PY - 2010/1/4

Y1 - 2010/1/4

N2 - Mast cell activation by immunoglobulin E (IgE)-mediated stimuli is a central event in the pathogenesis of allergic disorders. The present report shows that treatment with pentagalloylglucose (PGG) resulted in a down-regulation of FcεRI surface expression on mucosal-type murine bone marrow-derived mast cells (mBMMCs), which correlated with a reduction in IgE-mediated activation of mBMMCs. Furthermore, PGG prevented development of allergic diarrhea in a food-allergy mouse model and suppressed the up-regulated FcεRI surface expression on mast cells derived from the food-allergy mouse colon. These findings on PGG suggest its therapeutic potential for allergic diseases through suppressing the FcεRI surface expression.

AB - Mast cell activation by immunoglobulin E (IgE)-mediated stimuli is a central event in the pathogenesis of allergic disorders. The present report shows that treatment with pentagalloylglucose (PGG) resulted in a down-regulation of FcεRI surface expression on mucosal-type murine bone marrow-derived mast cells (mBMMCs), which correlated with a reduction in IgE-mediated activation of mBMMCs. Furthermore, PGG prevented development of allergic diarrhea in a food-allergy mouse model and suppressed the up-regulated FcεRI surface expression on mast cells derived from the food-allergy mouse colon. These findings on PGG suggest its therapeutic potential for allergic diseases through suppressing the FcεRI surface expression.

KW - Allergy

KW - Gene expression

KW - Mast cell

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U2 - 10.1016/j.febslet.2009.11.007

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Pentagalloylglucose down-regulates mast cell surface FcεRI expression in vitro and in vivo

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