@article{f9d8e4f480bd483dbc4eb72d67db80c8,
title = "αB-crystallin extracellularly suppresses ADP-induced granule secretion from human platelets",
abstract = "αB-crystallin, a low-molecular-weight heat shock protein (HSP), has binding sites on platelets. However, the exact role of αB-crystallin is not clarified. In this study, we investigated the effect of αB-crystallin on platelet granule secretion. αB-crystallin attenuated the adenosine diphosphate (ADP)-induced phosphorylation of p44/p42 mitogen-activated protein kinase (MAPK) and p38 MAPK. The ADP-stimulated HSP27 phosphorylation was markedly reduced by αB-crystallin. αB-crystallin significantly suppressed the ADP-induced secretions of both platelet-derived growth factor (PDGF)-AB and serotonin. Therefore, our results strongly suggest that αB-crystallin extracellularly suppresses platelet granule secretion by inhibition of HSP27 phosphorylation via p44/p42 MAPK and p38 MAPK.",
keywords = "Adenosine diphosphate, Heat shock protein, Platelet, Platelet-derived growth factor-AB, Serotonin, αB-crystallin",
author = "Yukiko Enomoto and Seiji Adachi and Rie Matsushima-Nishiwaki and Masayuki Niwa and Haruhiko Tokuda and Shigeru Akamatsu and Tomoaki Doi and Hisaaki Kato and Shinichi Yoshimura and Shinji Ogura and Toru Iwama and Osamu Kozawa",
note = "Funding Information: We are very grateful to Yoko Kawamura for her skillful technical assistance. This investigation was supported in part by Grants-in-Aid for Scientific Research (20590565 and 20591825) for the Ministry of Education, Science, Sports and Culture of Japan, the Research Grants for Longevity Sciences (17A-3), Research on Proteomics and Research on Longevity Sciences from the Ministry of Health, Labour and Welfare of Japan.",
year = "2009",
month = aug,
day = "6",
doi = "10.1016/j.febslet.2009.06.036",
language = "英語",
volume = "583",
pages = "2464--2468",
journal = "FEBS Letters",
issn = "0014-5793",
publisher = "John Wiley and Sons Inc.",
number = "15",
}