Development of electrochemical detection methods of biomolecules based on dynamics of biopolymer that immobilized on electrode

Recently, we have reported an electrochemical single nucleotide polymorphism detection by use of the ferrocene-modified DNA probe. In this study, new electrochemical methods based on dynamics of the probe molecules that immobilized on the electrode were developed in order to detect various biomolecules. For example: （1) We established an electrochemical detection method for insertion/deletion polymorphism by tuning the pulse potential frequency in square-wave voltammetry. （2) We developed an electrochemical protein detection method by using the new ferrocene-modified peptide probes.