Photoaffinity capture for the identification of functional site within proteins of nano-mol amount

Research output

Research output per year 2008 2009 2010 2011

• 13 Presentation
• 8 Article

Research output per year

Research output per year

Search results

• A Rapid and Efficient Method for Identifying Photoaffinity Labeled Sites within Proteins, Symposium for Medicinal Chemistry Division : Direct Approaches for Identifying All of the Cellular Targets of Small Molecule Drugs, and Mapping their Binding Cavities

  畑中保丸, 2010.

  Research output: Contribution to conference › Presentation

• Bouvier M., βアドレナリン受容体に特異的なジアジリン型新規光プローブの開発

  吉田幸司, 友廣岳則, 畑中保丸 & 小林弘幸, 2009.

  Research output: Contribution to conference › Presentation

• Chemical Approach for Identifying Drug Binding Site within Proteins

  畑中保丸, 2010.

  Research output: Contribution to conference › Presentation

• Chemical Approach for Identifying Drug Binding Site within Proteins基調講演(招待)

  Hatanaka, Y., 2010.

  Research output: Contribution to conference › Presentation

• Efficient approach for profiling photoaffinity labeled peptides with a cleavable biotinyl photoprobe

  Bongo, N. B., Tomohiro, T. & Hatanaka, Y., 2010/03/15, In: Bioorganic and Medicinal Chemistry Letters. 20, 6, p. 1834-1836 3 p.

  Research output: Contribution to journal › Article › peer-review

  • Labeled Peptide 100%
  • Photoaffinity 100%
  • Photoprobes 100%
  • Cleavable 100%
  • Iodoacetic Acid 100%
  6 Scopus citations

• Identification of a substrate-binding site in a peroxisomal β-oxidation enzyme by photoaffinity labeling with a novel palmitoyl derivative

  Kashiwayama, Y., Tomohiro, T., Narita, K., Suzumura, M., Glumoff, T., Hiltunen, J. K., Van Veldhoven, P. P., Hatanaka, Y. & Imanaka, T., 2010/08/20, In: Journal of Biological Chemistry. 285, 34, p. 26315-26325 11 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Palmitoyl-CoA 100%
  • Photoaffinity Labeling 100%
  • Peroxisomal 100%
  • Multifunctional Enzyme Type 2 100%
  • Substrate Binding Site 100%
  11 Scopus citations

• Photoactive ligands probing the sweet taste receptor. Design and synthesis of highly potent diazirinyl D-phenylalanine derivatives

  Masuda, K., Koizumi, A., Misaka, T., Hatanaka, Y., Abe, K., Tanaka, T., Ishiguro, M. & Hashimoto, M., 2010, In: Bioorg.Med.Chem.Lett. vol.20. p. 1081-1083

  Research output: Contribution to journal › Article › peer-review

• Photoaffinity-Based Binding Analysis of Pt-DamagedD DNA and Nclear Protein

  Tomohiro, T., Sugai, A., Hatanaka & Y., 2008.

  Research output: Contribution to conference › Presentation

• Photoaffinity-Based Binding Analysis of Pt-Damaged DNA and Nuclear Protein

  Tomohiro, T., 2008.

  Research output: Contribution to conference › Presentation

• Photoaffinity Labeling with Novel Cleavable Biotinyl Probe

  T., T., N.B., B. & Y., H., 2010.

  Research output: Contribution to conference › Presentation

• Rapidly photoactivatable ATP probes for specific labeling of tropomyosin within the actomvosin protein complex

  Masuda, S., Tomohiro, T. & Hatanaka, Y., 2011, In: Bioorg.Med.Chem.Lett. vol.20. 21(印刷中, in press (2011))

  Research output: Contribution to journal › Article › peer-review

• Rapidly photoactivatable ATP probes for specific labeling of tropomyosin within the actomyosin protein complex

  Masuda, S., Tomohiro, T. & Hatanaka, Y., 2011/04/15, In: Bioorganic and Medicinal Chemistry Letters. 21, 8, p. 2252-2254 3 p.

  Research output: Contribution to journal › Article › peer-review

  • Photoactivatable 100%
  • Adenosine Triphosphate 100%
  • Protein Complex 100%
  • Actomyosin 100%
  • Specific Labeling 100%
  6 Scopus citations

• Recent Progress in Diazirine-Based Photoaffinity Labeling

  Hahimoto, M. & Hatanaka, Y., 2008, In: Eur.J.Org.Chem. vol.2008. p. 2513-2523

  Research output: Contribution to journal › Article › peer-review

• Recent Progress in Diazirine-Based Photoaffinity Labeling(総説)

  Hashimoto, M., 2008, In: Eur.J.Org.Chem. vol.2008. p. 2513-2523

  Research output: Contribution to journal › Article › peer-review

• Synthesis and evaluation of novel photoreactive α-amino acid analog carrying acidic and cleavable functions

  Bongo, N. B., Tomohiro, T. & Hatanaka, Y., 2009/01/01, In: Bioorganic and Medicinal Chemistry Letters. 19, 1, p. 80-82 3 p.

  Research output: Contribution to journal › Article › peer-review

  • Photoreactive 100%
  • Acidic Amino Acid 100%
  • Cleavable 100%
  • Amino Acid Analogs 100%
  • Amino Acid 100%
  10 Scopus citations

• 味覚関連アミノ酸およびペプチド用光アフィニティーラベル試薬合成

  橋本誠 & 畑中保丸, 2010.

  Research output: Contribution to conference › Presentation

• 新ATP/ADPプローブによるアクトミオシン複合体の光アフィニティー解析

  増田宗太, 友廣岳則 & 畑中保丸, 2009.

  Research output: Contribution to conference › Presentation

• 新規ジアジリン導入シグナルペプチドプローブの開発

  森本正大, 2010.

  Research output: Contribution to conference › Presentation

• 発蛍光性ジアジリンとこれを導入した新規ATPプローブの開発

  猪ノ口裕二, 増田宗太, 友廣岳則 & 畑中保丸, 2010.

  Research output: Contribution to conference › Presentation

• 脂質、糖鎖、核酸等を一段階で光反応性プローブに誘導する効率的方法の開発

  谷下充佳, 友廣岳則 & 畑中保丸, 2009.

  Research output: Contribution to conference › Presentation

• 芳香族アミノ酸側鎖構造活性相関解析用光アフィニティーラベル試薬の立体選択的合成

  橋本誠, 村重諒, 村井勇太 & 畑中保丸, 2009.

  Research output: Contribution to conference › Presentation